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Automatic Macroporous Resin Absorbing Unit
The unit is specially designed, researched and developed for the purification of targeted compound in pharmaceutical industry. Senbofluid The preparative liquid chromatographic column has super high sample loading capacity, which has provided reliable guarantee for enhancing the preparative quantity of purification products with lower cost.
(Automation Control System) Based on the advanced DCS distributed control strategy, the workstation realizes the control and data acquisition of pumps, valves and various online detectors. Senbofluid It can easily complete multi-column series and parallel operation to ensure the stability and accuracy of the process.
Automatic control system
The system realizes the control and data acquisition of pumps, valves and various on-line detectors (flow rate transmission, pressure transmission), which can easily complete the four-column series and parallel operation to ensure the stability and accuracy of the process.
Structure of resin column
The resin column structure is well designed, reasonable height to diameter ratio, precise inlet and outlet fluid distribution device, equipped with automatic filling system and air compressed gas interface, ensuring the macroporous resin column filling effect and filler regeneration effect, providing high efficiency separation.
Online detection system for traditional Chinese medicine (optional) includes detection of routine process parameters such as flow, pressure, temperature, pH (optional), and conductivity (optional) and the use of ultraviolet spectroscopy (optional) and near-infrared spectroscopy Real-time detection of the content of active ingredients in traditional Chinese medicine.
The macroporous resin adsorption separation technology is a new separation and purification process for removing the ineffective components by using a special adsorbent to selectively adsorb the effective part from the Chinese herbal compound decoction. It can solve the practical problems of large doses, product moisture absorption and heavy metal residues in the production of traditional Chinese medicine. The refined product obtained by the macroporous resin adsorption technology can highly concentrate the medicinal ingredients, senbofluid and has less impurities, and the extraction yield is only 2 to 5% of the original drug, while the general boiling method is about 30%. The sedimentation method is about 15%; it can effectively remove moisture absorption components, is conducive to the production of a variety of medium dosage forms, and enhances the stability of the product; it can effectively remove heavy metals. The extract obtained by the macroporous resin adsorption separation process is small in volume, does not absorb moisture, and is easy to be made into various dosage forms with beautiful appearance, and is especially suitable for the production of granules, capsules, tablets, etc., so that the Chinese medicine is thick, large and black. The formulation is upgraded to a modern preparation. This technology will be one of the technological advances that have the greatest impact on the Chinese medicine extraction process and the widest driving range.
Introduce computer automatic monitoring technology in the separation process to realize production program control, automatic detection, pipeline transportation, and improve equipment reliability and repeatability.
Development of small test processes, scale-up studies of pilot processes, preparation of phytochemical standards, and reference materials. Widely used in the separation of phenols, aldehydes, alkaloids, amino acids, steroids, terpenoids, flavonoids, terpenoids, organic acids, glycosides, sugars, nucleosides and other pure products. Such as: paclitaxel, tea polyphenols, ginkgo flavonoids, bamboo leaf flavonoids, vitamin E and so on.
The chromatographic separation techniques used in the separation and purification of traditional Chinese medicine mainly include adsorption chromatography and ion exchange chromatography. Adsorption chromatography includes reversed phase chromatography (C18 reversed phase packing) and normal phase silica gel chromatography; senbofluid ion exchange chromatography is primarily used for the separation and purification of charged compounds. At present, chromatographic separation technology plays an increasingly important role in the refining of active ingredients of traditional Chinese medicines such as flavonoids, alkaloids, glycosides, organic acids and polysaccharides.
| Specification (L) | Inner tube diameter Φ (mm) | Jacket diameter Φ (mm) | Motor Power(Kw) | Reducer model | Stirring speed (r.p.m) |
|---|---|---|---|---|---|
| 30 | 400 | 500 | 0.6~1.1 | m2 | 60~85 |
| 50 | 500 | 600 | 0.6~1.1 | m3 | |
| 100 | 550 | 650 | 1.1~1.5 | m4 | |
| 150 | 600 | 700 | 2.2 | m6 | |
| 200 | 650 | 750 | |||
| 300 | 800 | 900 | |||
| 500 | 900 | 1000 | |||
| 800 | 1100 | 1200 | 4 | m8 | |
| 1000 | 1200 | 1300 | |||
| 1500 | 1300 | 1400 | |||
| 2000 | 1400 | 1500 | |||
| 2500 | 1400 | 1500 | 7.5 | BLB7.5-4-13 | 90 |
| 3000 | 1400 | 1500 | |||
| 3500 | 1400 | 1500 | |||
| 4000 | 1500 | 1600 | 63 | ||
| 5000 | 1600 | 1700 | |||
| 6000 | 1800 | 1800 | 15 | 100 | |
| 8000 | 2000 | 2100 | |||
| 32000 | 3000 | 3200 | 37 | BLB450-11-45 | 50~100 |
Experienced in supplying industrial fully automatic macroporous resin adsorption units
Familiar Pharmaceutical, food, and chemical industries processing projects
Strong customization and project coordination ability
Professional communication and fast response
Explosion-proof design
PLC automatic control system
CIP cleaning system
Vacuum or pressure vessel design
(steam, purified water, circulating water, chilled water, compressed air, nitrogen, vacuum, heating, etc.)
We can supply individual equipment or a complete turnkey extraction solution.
We provide complete technical support for extraction projects, including:
Process consultation and equipment selection
Process flow design and layout support
Equipment manufacturing and factory testing
Installation and commissioning guidance
Operator training and after-sales service
Export standard wooden case or steel frame
Suitable for sea and land transportation
Delivery terms: EXW / FOB / CIF
Process flow suggestion
Technical proposal
Budget estimation
Turnkey project solution
Automatic Macroporous Resin Absorbing Unit
The unit is specially designed, researched and developed for the purification of targeted compound in pharmaceutical industry. Senbofluid The preparative liquid chromatographic column has super high sample loading capacity, which has provided reliable guarantee for enhancing the preparative quantity of purification products with lower cost.
(Automation Control System) Based on the advanced DCS distributed control strategy, the workstation realizes the control and data acquisition of pumps, valves and various online detectors. Senbofluid It can easily complete multi-column series and parallel operation to ensure the stability and accuracy of the process.
Automatic control system
The system realizes the control and data acquisition of pumps, valves and various on-line detectors (flow rate transmission, pressure transmission), which can easily complete the four-column series and parallel operation to ensure the stability and accuracy of the process.
Structure of resin column
The resin column structure is well designed, reasonable height to diameter ratio, precise inlet and outlet fluid distribution device, equipped with automatic filling system and air compressed gas interface, ensuring the macroporous resin column filling effect and filler regeneration effect, providing high efficiency separation.
Online detection system for traditional Chinese medicine (optional) includes detection of routine process parameters such as flow, pressure, temperature, pH (optional), and conductivity (optional) and the use of ultraviolet spectroscopy (optional) and near-infrared spectroscopy Real-time detection of the content of active ingredients in traditional Chinese medicine.
The macroporous resin adsorption separation technology is a new separation and purification process for removing the ineffective components by using a special adsorbent to selectively adsorb the effective part from the Chinese herbal compound decoction. It can solve the practical problems of large doses, product moisture absorption and heavy metal residues in the production of traditional Chinese medicine. The refined product obtained by the macroporous resin adsorption technology can highly concentrate the medicinal ingredients, senbofluid and has less impurities, and the extraction yield is only 2 to 5% of the original drug, while the general boiling method is about 30%. The sedimentation method is about 15%; it can effectively remove moisture absorption components, is conducive to the production of a variety of medium dosage forms, and enhances the stability of the product; it can effectively remove heavy metals. The extract obtained by the macroporous resin adsorption separation process is small in volume, does not absorb moisture, and is easy to be made into various dosage forms with beautiful appearance, and is especially suitable for the production of granules, capsules, tablets, etc., so that the Chinese medicine is thick, large and black. The formulation is upgraded to a modern preparation. This technology will be one of the technological advances that have the greatest impact on the Chinese medicine extraction process and the widest driving range.
Introduce computer automatic monitoring technology in the separation process to realize production program control, automatic detection, pipeline transportation, and improve equipment reliability and repeatability.
Development of small test processes, scale-up studies of pilot processes, preparation of phytochemical standards, and reference materials. Widely used in the separation of phenols, aldehydes, alkaloids, amino acids, steroids, terpenoids, flavonoids, terpenoids, organic acids, glycosides, sugars, nucleosides and other pure products. Such as: paclitaxel, tea polyphenols, ginkgo flavonoids, bamboo leaf flavonoids, vitamin E and so on.
The chromatographic separation techniques used in the separation and purification of traditional Chinese medicine mainly include adsorption chromatography and ion exchange chromatography. Adsorption chromatography includes reversed phase chromatography (C18 reversed phase packing) and normal phase silica gel chromatography; senbofluid ion exchange chromatography is primarily used for the separation and purification of charged compounds. At present, chromatographic separation technology plays an increasingly important role in the refining of active ingredients of traditional Chinese medicines such as flavonoids, alkaloids, glycosides, organic acids and polysaccharides.
| Specification (L) | Inner tube diameter Φ (mm) | Jacket diameter Φ (mm) | Motor Power(Kw) | Reducer model | Stirring speed (r.p.m) |
|---|---|---|---|---|---|
| 30 | 400 | 500 | 0.6~1.1 | m2 | 60~85 |
| 50 | 500 | 600 | 0.6~1.1 | m3 | |
| 100 | 550 | 650 | 1.1~1.5 | m4 | |
| 150 | 600 | 700 | 2.2 | m6 | |
| 200 | 650 | 750 | |||
| 300 | 800 | 900 | |||
| 500 | 900 | 1000 | |||
| 800 | 1100 | 1200 | 4 | m8 | |
| 1000 | 1200 | 1300 | |||
| 1500 | 1300 | 1400 | |||
| 2000 | 1400 | 1500 | |||
| 2500 | 1400 | 1500 | 7.5 | BLB7.5-4-13 | 90 |
| 3000 | 1400 | 1500 | |||
| 3500 | 1400 | 1500 | |||
| 4000 | 1500 | 1600 | 63 | ||
| 5000 | 1600 | 1700 | |||
| 6000 | 1800 | 1800 | 15 | 100 | |
| 8000 | 2000 | 2100 | |||
| 32000 | 3000 | 3200 | 37 | BLB450-11-45 | 50~100 |
Experienced in supplying industrial fully automatic macroporous resin adsorption units
Familiar Pharmaceutical, food, and chemical industries processing projects
Strong customization and project coordination ability
Professional communication and fast response
Explosion-proof design
PLC automatic control system
CIP cleaning system
Vacuum or pressure vessel design
(steam, purified water, circulating water, chilled water, compressed air, nitrogen, vacuum, heating, etc.)
We can supply individual equipment or a complete turnkey extraction solution.
We provide complete technical support for extraction projects, including:
Process consultation and equipment selection
Process flow design and layout support
Equipment manufacturing and factory testing
Installation and commissioning guidance
Operator training and after-sales service
Export standard wooden case or steel frame
Suitable for sea and land transportation
Delivery terms: EXW / FOB / CIF
Process flow suggestion
Technical proposal
Budget estimation
Turnkey project solution